Scientific papers

In accordance with its mission to support high level research in Belgium, the University Foundation provides financial support towards the publication in high level international journals of scientific papers which report on research in Belgian research groups. Financial support may be granted to partially cover the costs due by the author for illustrations, for page charges and for article processing fees, and for linguuistic control. 

Because the possible support is restricted to Belgian research groups, the regulations and application procedures are only available in French  and in Dutch.

Articles subsidized by the University Foundation

What follows is a list of articles to which a subsidy was awarded by the University Foundation. The titles are ordered by year of publication and by title.

A.L. Jacquemart et al.

Jacquemart al. (2019) Male flowers of Aconitum compensate for toxic pollen with increased floral signals and rewards for pollinators.Scientific reports 9:16498 |

Many plants require animal pollinators for successful reproduction; these plants provide pollinator resources in pollen and nectar (rewards) and attract pollinators by specific cues (signals). In a seeming contradiction, some plants produce toxins such as alkaloids in their pollen and nectar, protecting their resources from ineffective pollinators.
Carole Charavet et al.

Charavet, C. et al (2019) Multilevel biological responses following piezocision to accelerate orthodontic tooth movement: A study in rats. Journal of the World Federation of Orthodontists.

Aim The objective of the present study was to explore the alveolar bone tissue response and its dynamic at the tissue, cellular, and molecular levels following a piezocision procedure in a rat model.

Sophie Opsomer, Peter Pype, Emelien Lauwerier, and Jan De Lepeleire

Opsomer, S. et al. (2019) Resilience in middle-aged partners of patients diagnosed with incurable cancer: A thematic analysis. PLoS One, Aug. 14, 2019.

Background Providing care for patients with advanced cancer is often the responsibility of the partner. Being confronted with an incurable cancer diagnosis can be highly disruptive for the patient’s partner and can be considered a potentially traumatic event. However, most caregivers seem to adapt well during the process of providing care. This finding is in line with the concept of resilience in literature: a dynamic process of adapting well, resulting from the interplay between intrinsic and extrinsic resources and risks.

Maria Papadopoulou, Paola Tieppo, Naomi McGovern, Françoise Gosselin, Jerry K. Y. Chan, Glenn Goetgeluk, Nicolas Dauby, Alexandra Cogan, Catherine Donner, Florent Ginhoux, Bart Vandekerckhove and David Vermijlen

Papadopoulou, M. et al. (2019) TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells. The Journal of Immunology, 203: 1468–1479. doi: 10.4049/jimmunol.1900592

Phosphoantigen-reactive Vγ9Vδ2 T cells represent the main innate human gd T cell subset and dominate the fetal and adult peripheral blood γδ T cell repertoire. It has been hypothesized that adult blood Vγ9Vδ2 T cells find their origin in the fetus like it is established for mouse innate γδ T cells. To address this issue, we analyzed the CDR3 of the TCR of human blood and thymic Vγ9Vδ2 T cells from fetal until adult life.

R. Neville et al.

Nivelle R. et al. (2019) Temperature preference of Nile tilapia (Oreochromis niloticus) juveniles induces spontaneous sex reversal. PLoS ONE 14(2): e0212504.

Nile tilapia (Oreochromis niloticus) is an African freshwater fish that displays a genetic sex determination system (XX|XY) where high temperatures (above 32°C to 36.5°C) induce masculinization. In Nile tilapia, the thermosensitive period was reported from 10 to 30 days post fertilization. In their natural environment, juveniles may encounter high temperatures that are above the optimal temperature for growth (27–30°C). The relevance of the thermal sex reversal mechanism in a natural context remains unclear.

M. Quinet et al.

Quinet M. et al. (2019) Tomato Fruit Development and MetabolismFrontiers in Plant Science 10:1554, doi: 10.3389/fpls.2019.01554.

Tomato (Solanum lycopersicum L.) belongs to the Solanaceae family and is the second most important fruit or vegetable crop next to potato (Solanum tuberosum L.). It is cultivated for fresh fruit and processed products. Tomatoes contain many healthpromoting compounds including vitamins, carotenoids, and phenolic compounds. In addition to its economic and nutritional importance, tomatoes have become the model for the study of fleshy fruit development. Tomato is a climacteric fruit and dramatic metabolic changes occur during its fruit development.
Vabutsele, G. et al.

Vanbutsele, G. et al. (2019) Use and timing of referral to specialized palliative care services for people with cancer: A mortality follow-back study among treating physicians in Belgium. Plos One.

Referral to specialized palliative care services (SPCS) occurs often late in the illness trajectory but may differ across cancer types. We examined differences between cancer types in the use and timing of referral to specialized palliative care services (SPCS) and in the reasons for non-referral.

Charisse Somers, Piotr Lewczuk, Anne Sieben, Christine Van Broeckhoven, Peter Paul De Deyn, Johannes Kornhuber, Jean-Jacques Martin, Maria Bjerke and Sebastiaan Engelborghs

Somers, C., Van Broeckhoven, C., Engelborghs, S et al. (2019) Validation of the Erlangen Score Algorithm for Differential Dementia Diagnosis in Autopsy-Confirmed Subjects. Journal of Alzheimer’s Disease 68, 1151–1159. DOI 10.3233/JAD-180563

Background: Despite decades of research on the optimization of the diagnosis of Alzheimer’s disease (AD), its biomarkerbased diagnosis is being hampered by the lack of comparability of raw biomarker data. In order to overcome this limitation, the Erlangen Score (ES), among other approaches, was set up as a diagnostic-relevant interpretation algorithm.
Objective: To validate the ES algorithm in a cohort of neuropathologically confirmed cases with AD (n = 106) and non-AD dementia (n = 57).
Jehan Seret et al.

Seret, J. et al. (2019) What Means A Quality Professional–Patient Relationship From The Asthmatic Patients’ Perspective? A Narrative Review Of Their Needs And Expectations, Patient Preference and Adherence, 13: 1951-1960,

Introduction: Poor treatment adherence among asthmatic patients currently remains a public health challenge. One of the most quoted determinants is the quality of the professional–patient relationship although it has clearly not been fully described.
Purpose: This study aims at deeply exploring asthmatic patients’ needs and expectations about the accompaniment proposed by their healthcare professionals.
Methods: A rigorous narrative review was performed.

Susan DIERICKX et al.

Dierickx, S. et al.(2019) Women with infertility complying with and resisting polygyny: an explorative qualitative study in urban GambiaReproductive Health vol .16, art. 103.

In many low-and middle-income countries women with infertility are often in polygynous marriages (i.e. marriages wherein men have multiple wives). In general, the practice of polygyny is understood to be harmful for women as it would have a negative impact on their health and general well-being. The purpose of this qualitative study is to explore how women with infertility experience polygyny and to understand their decision-making regarding these marriages. In-depth interviews were conducted between October 2017 and May 2018 in urban Gambia.

Koenraad Philippaert, Sara Kerselaers, Thomas Voets and Rudi Vennekens

Philippaert, K. et al. (2018)  A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels. SLAS Discovery.

TRPM5 functions as a calcium-activated monovalent cation-selective ion channel and is expressed in a variety of cell types. Dysfunction of this type of channel has been recently implied in cardiac arrhythmias, diabetes, and other pathologies. Therefore, a growing interest has emerged to develop the pharmacology of these ion channels. We optimized a screening assay based on the thallium flux through the TRPM5 channel and a fluorescent thallium dye as a probe for channel activity.

M. Klass et al.

Klaas M. et al (2018) Acute Effect of Noradrenergic Modulation on Motor Output Adjustment in MenMedicine & Science in Sports & Exercise.

Purpose: To determine the role of noradrenergic modulation in the control of motor output, we compared the acute effect of Reboxetine (REB), a noradrenaline reuptake inhibitor, to a placebo (PLA) on knee extensors motor performance and cortical and spinal excitability.

Ruth PIERS et al.

Piers, R. et al (2018) Advance care planning in dementia: recommendations for healthcare professionalsBMC Palliative Care, 2018, 17:88,

Background: Advance care planning (ACP) is a continuous, dynamic process of reflection and dialogue between an individual, those close to them and their healthcare professionals, concerning the individual’s preferences and values concerning future treatment and care, including end-of-life care.

Samia LAOKRI et al.

Laokri, S. et al (2018) Assessing out-of-pocket expenditures for primary health care: how responsive is the Democratic Republic of Congo health system to providing financial risk protection? BMC Health Services Research.

Background: The goal of universal health coverage is challenging for chronically under-resourced health systems. Although household out-of-pocket payments are the most important source of health financing in low-income countries, relatively little is known about the drivers of primary health care expenditure and the predictability of the burden associated with high fee-for-service payments.

Nathalie Biset et al.

Biset, N. et al. (2018)  Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill dataPatient Preference and Adherence 12 153–161.

Purpose: The aims of the study were to evaluate medication adherence and the influencing factors for isotretinoin and contraception (oral, patches, and rings) and to evaluate the concomitant use of contraception and isotretinoin.