In accordance with its mission to support high level research in Belgium, the University Foundation provides financial support towards the publication in high level international journals of scientific papers which report on research in Belgian research groups. Financial support may be granted to partially cover the costs due by the author for illustrations, for page charges and for article processing fees, and for linguuistic control.
What follows is a list of articles to which a subsidy was awarded by the University Foundation. The titles are ordered by year of publication and by title.
Brock S, Vanderhasselt T, Vermaning S, et al. (2021) Defining the phenotypical spectrum associated with variants in TUBB2A. Journal of Medical Genetics, 58:33–40. doi:10.1136/jmedgenet-2019-106740
Abstract : Background Variants in genes belonging to the tubulin superfamily account for a heterogeneous spectrum of brain malformations referred to as tubulinopathies. Variants in TUBB2A have been reported in 10 patients with a broad spectrum of brain imaging features, ranging from a normal cortex to polymicrogyria, while one patient has been reported with progressive atrophy of the cerebellar vermis.
Detection of Cryptic Sex in Automictic Populations: Theoretical Expectations and a Case Study in Cataglyphis Desert Ants
Disentangling the effects of CAD/CAM customized appliances and piezocision in orthodontic treatment: New evidence
Objectives: To discern the effects of computer-aided design (CAD)/computer-aided manufactured (CAM) customized appliances and piezocision on orthodontic treatment (OT).
Efficient optimization methodology for laser powder bed fusion parameters to manufacture dense and mechanically sound parts validated on AlSi12 alloy
Gheysen, J., Marteleur, M., van der Rest, C., Simar, A. (2021) Efficient optimization methodology for laser powder bed fusion parameters to manufacture dense and mechanically sound parts validated on AlSi12 alloy. Materials & Design, Volume 199, 109433. https://doi.org/10.1016/j.matdes.2020.109433
Abstract : The main drawback of laser powder bed fusion (L-PBF), commonly called selective laser melting (SLM) is the high porosity which may lead to an early failure of the parts. To minimize it, the L-PBF parameters need to be optimized focusing on the laser power, scanning speed and hatching space. However, no standard guideline exists. In this study, an efficient and cost-effective methodology is developed and validated on AlSi12. This innovative methodology brings together single scan tracks (SST), macroscopic properties analysis and design of experiments (DOE).
Verdikt, R. † , Hernalsteens, O and Van Lint, C. (2021) Epigenetic Mechanisms of HIV-1 Persistence. Vaccines, 9, 514. https://doi.org/10.3390/vaccines9050514
Abstract : Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized therapeutic interventions. HIV-1 geneexpression relies on the redundant and cooperative recruitment of cellular epigenetic machineries to cis-regulatory proviral regions.
Pigeolet, M. et al. (2021) Evaluation of a surgical treatment algorithm for neglected clubfoot in low‑resource settings. International Orthopaedics. https://doi.org/10.1007/s00264-021-05058-6
Purpose : Idiopathic clubfoot affects approximately 1/1000 alive-born infants, of whom 80–91% are born in low- or middleincome countries (LMICs). This retrospective study aimed to evaluate the morphological, functional, and social outcomes in patients with neglected clubfoot in rural Bangladesh, after receiving surgical treatment.
Evidence of past forest fragmentation in the Congo Basin from the phylogeography of a shade-tolerant tree with limited seed dispersal: Scorodophloeus zenkeri (Fabaceae, Detarioideae)
Vanden Abeele et al. (2021) Evidence of past forest fragmentation in the Congo Basin from the phylogeography of a shade-tolerant tree with limited seed dispersal: Scorodophloeus zenkeri (Fabaceae, Detarioideae) BMC Ecology and Evolution https://doi.org/10.1186/s12862-021-01781-1
Background: Comparative phylogeographic studies on rainforest species that are widespread in Central Africa often reveal genetic discontinuities within and between biogeographic regions, indicating (historical) barriers to gene flow, possibly due to repeated and/or long-lasting population fragmentation during glacial periods according to the forest refuge hypothesis. The impact of forest fragmentation seems to be modulated by the ecological amplitude and dispersal capacities of each species, resulting in different demographic histories.
Fatigue crack nucleation and growth in laser powder bed fusion AlSi10Mg under as built and post-treated conditions
Santos Macías, Elangeswaran, Zhao et al. (2021) Fatigue crack nucleation and growth in laser powder bed fusion AlSi10Mg under as built and post-treated conditions. Materials & Design 210 https://doi.org/10.1016/j.matdes.2021.110084
Abstract : Numerous efforts have been devoted to produce reliable additive manufactured (AM) materials for structural applications. However, the critical fatigue issue poses a significant hurdle in relation to the nature of this production method. Despite the relative flexibility of the laser powder bed fusion (LPBF) AM process, there exists a limitation in the possibility of tailoring parameters to obtain a satisfactory combination of porosity and surface roughness for adequate fatigue resistance.
Increased brain atrophy and lesion load is associated with stronger lower alpha MEG power in multiple sclerosis patients
Van Schependom, J. et al. (2021) Increased brain atrophy and lesion load is associated with stronger lower alpha MEG power in multiple sclerosis patients NeuroImage: Clinical Volume 30, 102632 DOI: 10.1016/j.nicl.2021.102632
Abstract: In multiple sclerosis, the interplay of neurodegeneration, demyelination and inflammation leads to changes in neurophysiological functioning. This study aims to characterize the relation between reduced brain volumes and spectral power in multiple sclerosis patients and matched healthy subjects. During resting-state eyes closed, we collected magnetoencephalographic data in 67 multiple sclerosis patients and 47 healthy subjects, matched for age and gender. Additionally, we quantified different brain volumes through magnetic resonance imaging (MRI).
Listening to a Dysphonic Speaker in Noise May Impede Children’s Spoken Language Processing in a Realistic Classroom Setting
Schiller I., Morsomme D., Kob M. & Remacle A. (2021) Listening to a Dysphonic Speaker in Noise May Impede Children’s Spoken Language Processing in a Realistic Classroom Setting. Language, Speech, and Hearing Services in Schools Vol. 52, 396–408.
Purpose The aim of this study was to investigate children's processing of dysphonic speech in a realistic classroom setting, under the influence of added classroom noise.
Abstract : Aristotelian diagrams, such as the square of opposition, are well-known in the context of normal modal logics (i.e., systems of modal logic which can be given a relational semantics in terms of Kripke models). This paper studies Aristotelian diagrams for non-normal systems of modal logic (based on neighborhood semantics, a topologically inspired generalization of relational semantics). In particular, we investigate the phenomenon of logic-sensitivity of Aristotelian diagrams. We distinguish between four different types of logic-sensitivity, viz.
De Moor, H. (2021) Netherlandish carved altarpieces: a historiographic overview with a focus on Sweden in Journal of Art Historiography Number 25, https://arthistoriography.files.wordpress.com/2021/11/de-moor.pdf
Burgeon, C., (2021) Past, present, and future trends in boar taint detection Trends in Food Science and Technology, Volume 112, 283-297 https://doi.org/10.1016/j.tifs.2021.04.007
Boar taint is an unpleasant smell found in the meat of some uncastrated male pigs. This taint is often prevented by surgical castration without anesthesia or analgesia. However, this practice is an animal welfare concern. Production of entire males and immunocastration were suggested as alternatives. Ensuring that meat is untainted remains a priority for slaughterhouses. This has initiated research about the development of new boar taint detection methods. Most focus on detecting skatole and androstenone, two major contributors to boar taint.
Peptide-Conjugated Silver Nanoparticles for the Colorimetric Detection of the Oncoprotein Mdm2 in Human Serum
Retout M., ,Gosselin B.,Mattiuzzi A.,Ternad I., Jabin I, and Bruylants G., Peptide-Conjugated Silver Nanoparticles for the Colorimetric Detection of the Oncoprotein Mdm2 in Human Serum, ChemPlusCjhem, vol.87, issue 4.
The development of efficient, reliable, and easy-to-use biosensors allowing early cancer diagnosis is of paramount importance for patients. Herein, we report a biosensor based on silver nanoparticles functionalized by peptide aptamers for the detection of a cancer biomarker, i. e. the Mdm2 protein. Silver nanoparticles (AgNPs) were produced and stabilized with a thin PEGylated-calixarene layer that allows (i) the steric stabilization of the AgNPs and (ii) the covalent conjugation of the peptide aptamers via the formation of an amide bond.
Nea, F., et al. (2021) Phytochemical Investigation and Biological Activities of Lantana rhodesiensis. Molecules 26, 846. https://doi.org/10.3390/molecules26040846
Abstract: Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a phytochemical study was undertaken, revealing a higher proportion of polyphenols, including flavonoids in L. rhodesiensis leaf extract and moderate proportion in stem and root extracts.