In accordance with its mission to support high level research in Belgium, the University Foundation provides financial support towards the publication in high level international journals of scientific papers which report on research in Belgian research groups. Financial support may be granted to partially cover the costs due by the author for illustrations, for page charges and for article processing fees, and for linguuistic control.
What follows is a list of articles to which a subsidy was awarded by the University Foundation. The titles are ordered by year of publication and by title.
Exploiting Genomic Features to Improve the Prediction of Transcription Factor-Binding Sites in Plants
Rivière, Q. et al. (2022) Exploiting Genomic Features to Improve the Prediction of Transcription Factor-Binding Sites in Plants. Plant and Cell Physiology.
The identification of transcription factor (TF) target genes is central in biology. A popular approach is based on thelocation by pattern matching of potential cis-regulatory elements (CREs). During the last few years, tools integrating next-generation sequencing data have been developed to improve the performance of pattern matching. However, such tools have not yet been comprehensively evaluated in plants. Hence, we developed a new streamlined method aiming at predicting CREs and target genes of plant TFs in specific organs or conditions.
From maternal breath to infant’s cells: Impact of maternal respiratory infections on infants ‘immune responses
Dauby N and Flamand V (2022) From maternal breath to infant’s cells: Impact of maternal respiratory infections on infants ‘immune responses. Front. Pediatr. 10:1046100. doi: 10.3389/fped.2022.1046100.
In utero exposure to maternally-derived antigens following chronic infection is associated with modulation of infants ‘immune response, differential susceptibility to post-natal infections and immune response toward vaccines. The maternal environment, both internal (microbiota) and external (exposure to environmental microbes) also modulates infant’s immune response but also the clinical phenotype after birth.
Glycemic Variability Patterns Strongly Correlate With Partial Remission Status in Children With Newly Diagnosed Type 1 Diabetes
Pollé O.G et al. Glycemic Variability Patterns Strongly Correlate With Partial Remission Status in Children With Newly Diagnosed Type 1 Diabetes. Diabetes Care vol. 45, pp.2360-2368. https://doi.org/10.2337/dc21-2543
To evaluate whether indexes of glycemic variability may overcome residual b-cell secretion estimates in the longitudinal evaluation of partial remission in a cohort of pediatric patients with new-onset type 1 diabetes.
RESEARCH DESIGN AND METHODS
Improving public health through the development of local scientific capacity and training in rehabilitation in LMICs.
Bonnechère B, Kossi O, Adoukonou T, Coninx K, Spooren A and Feys P (2022) Improving public health through the development of local scientific capacity and training in rehabilitation in LMICs: A proof-of-concept of collaborative efforts in Parakou, Benin. Front. Public Health 10:952727. doi: 10.3389/fpubh.2022.952727
The increase in life expectancy is linked, among other factors such as genetic factors, environmental factors, factors of medical conditions, socio-demographic factors, self-management, and access to care, to an increase in non-communicable diseases (NCDs), which puts huge pressure on the health care systems. Cardiovascular diseases are, by far, the most common NCD in low- to middle-income countries (LMICs); among these diseases, stroke is the most frequent (3).
Abstract: Although Erythrina senegalensis is a plant widely used in traditional medicine in sub-Saharan Africa, its biological properties have been poorly investigated to date. We first characterized by conventional reactions the composition of several stem bark extracts and evaluated in acellular and cellular assays their pro- or antioxidant properties supported by their high phenolic and flavonoid content, particularly with the methanolic extract.
Indoor Summer Thermal Comfort in a Changing Climate: The Case of a Nearly Zero Energy House in Wallonia (Belgium)
Differences in language use and structures between signed and spoken languages have often been attributed to so-called language “modality.” Indeed, this is derived from the conception that spoken languages resort to both the oral-aural channel of speech and the visual-kinesic channel of visible bodily action whereas signed languages only resort to the latter. This paper addresses the use of enactment, a depictive communicative strategy whereby language users imitate referents in signed and spoken languages.
Interprofessional Identity in Health and Social Care: Analysis and Synthesis of the Assumptions and Conceptions in the Literature
Cantaert G.R, Pype P., Valcke M., and Lauwerier E. (2022) Interprofessional Identity in Health and Social Care: Analysis and Synthesis of the Assumptions and Conceptions in the Literature. International Journal of Environmental Research and Public Health, 19, 14799.
Interprofessional identity (IPI) development is considered essential in reducing incongruency and improving interprofessional collaboration. However, noticeable differences in conceptualizations are being put forward in the literature, hindering interpretation of research findings and translation into practice. Therefore, a Concept Analysis and Critical Interpretative Synthesis of empirical research articles were conducted to explore the assumptions and conceptions of IPI. Independent literature screening by two researchers led to the inclusion and extraction of 39 out of 1334 articles.
Based on evidence that learning new characters through handwriting leads to better recognition than learning through typing, some authors proposed that the graphic motor plans acquired through handwriting contribute to recognition. More recently two alternative explanations have been put forward. First, the advantage of handwriting could be due to the perceptual variability that it provides during learning. Second, a recent study suggests that detailed visual analysis might be the source of the advantage of handwriting over typing.
Nephroprotective Effects of Two Ganoderma Species Methanolic Extracts in an In Vitro Model of Cisplatin Induced Tubulotoxicity
Antoine, M.-H.;Welti, S.; Stévigny, C.; Nortier, J. Nephroprotective Effects of Two Ganoderma Species Methanolic Extracts in an In Vitro Model of Cisplatin Induced Tubulotoxicity. J. Fungi 2022, 8, 1002. https://doi.org/10.3390/jof8101002
Although cisplatin is used as a first-line therapy in many cancers, its nephrotoxicity remains a real problem. Acute kidney injuries induced by cisplatin can cause proximal tubular necrosis, possibly leading to interstitial fibrosis, chronic dysfunction, and finally to a cessation of chemotherapy. There are only a few nephroprotective actions that can help reduce cisplatin nephrotoxicity. This study aims to identify new prophylactic properties with respect to medicinal mushrooms.
Tori F. & Ginis V. Phase space approach to solving higher order differential equations with artificial neural networks. Physical Review Research vol. 4, 043090.
The ability to solve differential equations represents a key step in the modeling and understanding of complex systems. There exist several analytical and numerical methods for solving differential equations, each with their own advantages and limitations. Physics-informed neural networks (PINNs) offer an alternative perspective. Although PINNs deliver promising results, many stones remain unturned about this method. In this paper, we introduce a method that improves the efficiency of PINNs in solving differential equations.
Physicians’ Experiences and Perceptions of Environmental Factors Affecting Their Practices of Continuous Deep Sedation until Death: A Secondary Qualitative Analysis of an Interview Study
As previous research has paid little attention to environmental factors affecting the practice of continuous deep sedation until death (CDS), we aimed to explore these using physicians’ experiences and perceptions.
Opsomer S, Lauwerier E, De Lepeleire J, Pype P. Resilience in advanced cancer caregiving. A systematic review and meta-synthesis. Palliative Medicine. 2022;36(1):44-58. doi:10.1177/02692163211057749
Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization
Bellefroid M, Rodari A, et al. (2022) Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization. Nucleic Acids Res. Apr 8;50(6):3190-3202. doi: 10.1093/nar/gkac107. PMID: 35234910; PMCID: PMC8989512.
Bovine leukemia virus (BLV)-induced tumoral development is a multifactorial phenomenon that remains incompletely understood. Here, we highlight the critical role of the cellular CCCTC-binding factor (CTCF) both in the regulation of BLV transcriptional activities and in the deregulation of the three-dimensional (3D) chromatin architecture surrounding the BLV integration site. We demonstrated the in vivo recruitment of CTCF to three conserved CTCF binding motifs along the provirus.