Scientific papers

In accordance with its mission to support high level research in Belgium, the University Foundation provides financial support towards the publication in high level international journals of scientific papers which report on research in Belgian research groups. Financial support may be granted to partially cover the costs due by the author for illustrations, for page charges and for article processing fees, and for linguuistic control. 

Because the possible support is restricted to Belgian research groups, the regulations and application procedures are only available in French  and in Dutch.

Articles subsidized by the University Foundation

What follows is a list of articles to which a subsidy was awarded by the University Foundation. The titles are ordered by year of publication and by title.

Charisse Somers, Piotr Lewczuk, Anne Sieben, Christine Van Broeckhoven, Peter Paul De Deyn, Johannes Kornhuber, Jean-Jacques Martin, Maria Bjerke and Sebastiaan Engelborghs

Somers, C., Van Broeckhoven, C., Engelborghs, S et al. (2019) Validation of the Erlangen Score Algorithm for Differential Dementia Diagnosis in Autopsy-Confirmed Subjects. Journal of Alzheimer’s Disease 68, 1151–1159. DOI 10.3233/JAD-180563

Background: Despite decades of research on the optimization of the diagnosis of Alzheimer’s disease (AD), its biomarkerbased diagnosis is being hampered by the lack of comparability of raw biomarker data. In order to overcome this limitation, the Erlangen Score (ES), among other approaches, was set up as a diagnostic-relevant interpretation algorithm.
Objective: To validate the ES algorithm in a cohort of neuropathologically confirmed cases with AD (n = 106) and non-AD dementia (n = 57).
Jehan Seret et al.

Seret, J. et al. (2019) What Means A Quality Professional–Patient Relationship From The Asthmatic Patients’ Perspective? A Narrative Review Of Their Needs And Expectations, Patient Preference and Adherence, 13: 1951-1960,

Introduction: Poor treatment adherence among asthmatic patients currently remains a public health challenge. One of the most quoted determinants is the quality of the professional–patient relationship although it has clearly not been fully described.
Purpose: This study aims at deeply exploring asthmatic patients’ needs and expectations about the accompaniment proposed by their healthcare professionals.
Methods: A rigorous narrative review was performed.

Susan DIERICKX et al.

Dierickx, S. et al.(2019) Women with infertility complying with and resisting polygyny: an explorative qualitative study in urban GambiaReproductive Health vol .16, art. 103.

In many low-and middle-income countries women with infertility are often in polygynous marriages (i.e. marriages wherein men have multiple wives). In general, the practice of polygyny is understood to be harmful for women as it would have a negative impact on their health and general well-being. The purpose of this qualitative study is to explore how women with infertility experience polygyny and to understand their decision-making regarding these marriages. In-depth interviews were conducted between October 2017 and May 2018 in urban Gambia.

Koenraad Philippaert, Sara Kerselaers, Thomas Voets and Rudi Vennekens

Philippaert, K. et al. (2018)  A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels. SLAS Discovery.

TRPM5 functions as a calcium-activated monovalent cation-selective ion channel and is expressed in a variety of cell types. Dysfunction of this type of channel has been recently implied in cardiac arrhythmias, diabetes, and other pathologies. Therefore, a growing interest has emerged to develop the pharmacology of these ion channels. We optimized a screening assay based on the thallium flux through the TRPM5 channel and a fluorescent thallium dye as a probe for channel activity.

M. Klass et al.

Klaas M. et al (2018) Acute Effect of Noradrenergic Modulation on Motor Output Adjustment in MenMedicine & Science in Sports & Exercise.

Purpose: To determine the role of noradrenergic modulation in the control of motor output, we compared the acute effect of Reboxetine (REB), a noradrenaline reuptake inhibitor, to a placebo (PLA) on knee extensors motor performance and cortical and spinal excitability.

Ruth PIERS et al.

Piers, R. et al (2018) Advance care planning in dementia: recommendations for healthcare professionalsBMC Palliative Care, 2018, 17:88,

Background: Advance care planning (ACP) is a continuous, dynamic process of reflection and dialogue between an individual, those close to them and their healthcare professionals, concerning the individual’s preferences and values concerning future treatment and care, including end-of-life care.

Samia LAOKRI et al.

Laokri, S. et al (2018) Assessing out-of-pocket expenditures for primary health care: how responsive is the Democratic Republic of Congo health system to providing financial risk protection? BMC Health Services Research.

Background: The goal of universal health coverage is challenging for chronically under-resourced health systems. Although household out-of-pocket payments are the most important source of health financing in low-income countries, relatively little is known about the drivers of primary health care expenditure and the predictability of the burden associated with high fee-for-service payments.

Nathalie Biset et al.

Biset, N. et al. (2018)  Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill dataPatient Preference and Adherence 12 153–161.

Purpose: The aims of the study were to evaluate medication adherence and the influencing factors for isotretinoin and contraception (oral, patches, and rings) and to evaluate the concomitant use of contraception and isotretinoin.

Sylvia FAICT et al.

Faict, S. et al. (2018) Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts. Blood Cancer Journal 8:105

Progression of multiple myeloma (MM) is largely dependent on the bone marrow (BM) microenvironment wherein communication through different factors including extracellular vesicles takes place. This cross-talk not only leads to drug resistance but also to the development of osteolysis. Targeting vesicle secretion could therefore simultaneously ameliorate drug response and bone disease. In this paper, we examined the effects of MM exosomes on different aspects of osteolysis using the 5TGM1 murine model.

Kim De Veirman et al.

De Veirman, K. et al. (2018) Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion.  Cancer Immunol Res. 5(10), 839–46. 

Dysregulated expression of S100 protein family members is associated with cancer proliferation, invasion, angiogenesis, and inflammation. S100A9 induces myeloid-derived suppressor cell (MDSC) accumulation and activity. MDSCs, immunosuppressive cells that contribute to tumor immune escape, are the main producers of S100A9.
Joni Gilissen et al.

Gilissen, J. et al. How to achieve the desired outcomes of advance care planning in nursing homes: a theory of change BMC Geriatrics (2018, 18:47 DOI 10.1186/s12877-018-0723-5.

Background: Advance care planning (ACP) has been identified as particularly relevant for nursing home residents, but it remains unclear how or under what circumstances ACP works and can best be implemented in such settings. We aimed to develop a theory that outlines the hypothetical causal pathway of ACP in nursing homes, i.e. what changes are expected, by means of which processes and under what circumstances.
Mélanie LELUBRE et al.

Lelubre;, M. et al. (2018) Implementation study of an intermediate medication review in Belgian community pharmacies. Research in Social and Administrative Pharmacy.

Background: The Association of Pharmacists in Belgium (APB) and local pharmacy associations launched a pilot project in collaboration with research teams from three Belgian universities to study the impact and implementation- related issues of a medication review (MR) service type 2a in Belgian community pharmacies. Objective: The aim of this paper is to describe the implementation process of the MR service and to present the implementation evaluation of the pilot study (testing stage).
Mouctor SOW et al.

Sow, M. et al. (2018) Is the socioeconomic status of immigrant mothers in Brussels relevant to predict their risk of adverse pregnancy outcomes? BMC Pregnancy and Childbirth. 2018, 118:422.

Background: Understanding and tackling perinatal health inequities in industrialized countries requires analysing the socioeconomic determinants of adverse pregnancy outcomes among immigrant populations. Studies show that among certain migrant groups, education is not associated with adverse pregnancy outcomes. We aim to extend this analysis to further dimensions of socioeconomic status (SES) and to other settings.

A. Woller & D. Gonze

A. Woller & D. Gonze (2018) Modeling clock-related metabolic syndrome due to conflicting light and food cues, Scientific Reports 8:13641 | DOI:10.1038/s41598-018-31804-9.

Most organisms possess a light- and food- entrainable circadian clock system enabling their adaptation to daily environmental changes in sunlight and food availability. The mammalian circadian system is composed of multiple clocks throughout the body.
Didier GONZE et al.

Gonze, D. et al. (2018) Modeling-Based Investigation of the Effect of Noise in Cellular Systems, Frontiers in Molecular Biosciences, vol 5, April 2018.


Noise is pervasive in cellular biology and inevitably affects the dynamics of cellular processes.
Biological systems have developed regulatory mechanisms to ensure robustness with respect to noise or to take advantage of stochasticity. We review here, through a couple of selected examples, some insights on possible robustness factors and constructive roles of noise provided by computational modeling. In particular, we focus on