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Wat volgt is een lijst van wetenschappelijke artikelen die recent gesubsidieerd werden door de Universitaire Stichting. De artikelen zijn gesorteerd op jaar van uitgave en per titel.
Gonze, D. et al. (2018) Modeling-Based Investigation of the Effect of Noise in Cellular Systems, Frontiers in Molecular Biosciences, vol 5, April 2018.
Noise is pervasive in cellular biology and inevitably affects the dynamics of cellular processes.
Biological systems have developed regulatory mechanisms to ensure robustness with respect to noise or to take advantage of stochasticity. We review here, through a couple of selected examples, some insights on possible robustness factors and constructive roles of noise provided by computational modeling. In particular, we focus on
New insights into the biosynthesis of esterified oxylipins and their involvement in plant defense and developmental mechanisms
Genva, M. et al. (2018) New insights into the biosynthesis of esterified oxylipins and their involvement in plant defense and developmental mechanisms. Phytochemistry Reviews.
Plant oxylipins produced following oxidation of unsaturated fatty acids are structurally diverse metabolites that play crucial developmental and defensive roles. Whereas free oxylipins are well studied, oxylipins esterified in complex lipids such as galacto- and phospholipids are thought to be rare and have unclear roles. In the last few years, new analytical methods have been developed, leading to the discovery of many esterified oxylipins in a variety of plant species. This suggests that these molecules may be ubiquitous plant metabolites.
Off-Target and Tumor-Specific Accumulation of Monocytes, Macrophages and Myeloid-Derived Suppressor Cells after Systemic Injection
Combes, F. et al. (2018) Off-Target and Tumor-Specific Accumulation of Monocytes, Macrophages and Myeloid-Derived Suppressor Cells after Systemic Injection. Neoplasia vol 20 (8) pp. 848-856.
Solid tumors frequently coexist with a degree of local chronic inflammation. Recruited myeloid cells can therefore be considered as interesting vehicles for tumor-targeted delivery of therapeutic agents. Using in vivo imaging, the short-term accumulation of systemically injected monocytes, macrophages and myeloid-derived suppressor cells (MDSCs) was compared in mice bearing fat pad mammary carcinomas.
Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade
Dewaele, J. et al. (2018) Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade. OncoImmunology, vol. 7 no 3.
Prognosis of glioblastoma remains dismal, underscoring the need for novel therapies. Immunotherapy is generating promising results, but requires combination strategies to unlock its full potential. We investigated the immunomodulatory capacities of poly(I:C) on primary human glioblastoma cells and its combinatorial potential with programmed death ligand (PD-L) blockade. In our experiments, poly(I:C) stimulated expression of both PD-L1 and PD-L2 on glioblastoma cells, and a pro-inflammatory secretome, including type I interferons (IFN) and chemokines CXCL9, CXCL10, CCL4 and CCL5.
Student researchers’ perceived prerequisites for voluntary research collaboration in the context of Flemish and Chinese universities
Li S, Zhu C, Li S (2018) Student researchers’ perceived prerequisites for voluntary research collaboration in the context of Flemish and Chinese universities. PLoS ONE 13(5): e0197960. https://doi.org/10.1371/journal.pone.0197960
While numerous papers have illuminated the worthiness of research collaboration, relatively few have addressed its prerequisites. In our study, seven prerequisites for research collaboration were extracted from the existing literature, and 460 student researchers were surveyed for their perceptions of the prerequisites’ importance.
Submerging a Biomimetic Metallo-Receptor in Water for Anion Recognition: Micellar Incorporation or Water Solubilization? A Case Study
Collin, S. (2018) Submerging a Biomimetic Metallo-Receptor in Water for Anion Recognition: Micellar Incorporation or Water Solubilization? A Case Study. Chem.Eur. J. vol. 24, pp. 17964-17974.
Molecular recognition in water is an important topic, but a challenging task due to the very competitive nature of the medium. The focus of this study is the comparison of two different strategies for the water solubilization of a biomimetic metallo‐receptor based on a poly(imidazole) resorcinarene core. The first relies on a new synthetic path for the introduction of hydrophilic substituents on the receptor, at a remote distance from the coordination site.
Calderon, C.B. et al. (2018) Task-Relevant Information Modulates Primary Motor Cortex Activity Before Movement Onset.Frontiers in Human Neuroscience,Volume 12, Article 93.
Temperature and water stress affect plant–pollinator interactions in Borago officinalis (Boraginaceae)
Descamps, C. et al. (2018) Temperature and water stress affect plant–pollinator interactions in Borago officinalis (Boraginaceae).Ecology and Evolution, vol. 8, 3443 –3456.
Climate change alters the abiotic constraints faced by plants, including increasing temperature and water stress. These changes may affect flower evelopment and production of flower rewards, thus altering plant–pollinator interactions. Here, we investigated the consequences of increased temperature and water stress on plant growth, floral biology, flower-reward production, and insect visitation of a widespread bee-visited species, Borago officin alis. Plants were grown for 5 weeks under three temperature regimes (21, 24, and 27°C) and two watering regimes (well-watered and water-stressed).
The Future of Freshwater Macrophytes in a Changing World: Dissolved Organic Carbon Quantity and Quality and Its Interactions With Macrophytes
Reitseman R.E. et al. (2018) The Future of Freshwater Macrophytes in a Changing World: Dissolved Organic Carbon Quantity and Quality and Its Interactions With Macrophytes. Frontiers in Plant Science, Functional Plant Ecology, May 2018.
The influence of soil properties and nutrients on conifer forest growth in Sweden, and the first steps in developing a nutrient availability metric
Van Sundert, K. et al. (2018) The influence of soil properties and nutrients on conifer forest growth in Sweden, and the first steps in developing a nutrient availability metric. Biogeosciences, 15, 3475–3496, 2018, https://doi.org/10.5194/bg-15-3475-2018.
The availability of nutrients is one of the factors that regulate terrestrial carbon cycling and modify ecosystem responses to environmental changes. Nonetheless, nutrient availability is often overlooked in climate–carbon cycle studies because it depends on the interplay of various soil factors that would ideally be comprised into metrics applicable at large spatial scales. Such metrics do not currently exist.
‘I am always crying on the inside’: a qualitative study on the implications of infertility on women’s lives in urban Gambia
Dierickx S. et al. (2018) ‘I am always crying on the inside’: a qualitative study on the implications of infertility on women’s lives in urban Gambia. Reproductive Health 15:151, https://doi.org/10.1186/s12978-018-0596-2
Tosenberger, A. et al. (2017) A multiscale model of early cell lineage specification including cell division, npj Systems Biology and Applications (2017) 3:16 ; doi:10.1038/s41540-017-0017-0.
Embryonic development is a self-organised process during which cells divide, interact, change fate according to a complex gene regulatory network and organise themselves in a three-dimensional space. Here, we model this complex dynamic phenomenon in the context of the acquisition of epiblast and primitive endoderm identities within the inner cell mass of the preimplantation embryo in the mouse. The multiscale model describes cell division and interactions between cells, as well as biochemical reactions inside each individual cell and in the extracellular matrix.
Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
Houbracken, I. and Bouwens, L. (2017) Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells. Scientific Reports 7, Article number: 12643. doi:10.1038/s41598-017-12721-9.
Pancreatic acinar cells secrete digestive enzymes necessary for nutrient digestion in the intestine. They are considered the initiating cell type of pancreatic cancer and are endowed with differentiation plasticity that has been harnessed to regenerate endocrine beta cells. However, there is still uncertainty about the mechanisms of acinar cell formation during the dynamic period of early postnatal development.
EEG dominant frequency peak differentiates between Alzheimer’s disease and frontotemporal lobar degeneration
Goossens, J. et al (2017) EEG dominant frequency peak differentiates between Alzheimer’s disease and frontotemporal lobar degeneration. Journal of Alzheimer’s Disease vol. 55 pp. 53-58.
We investigated the power of EEG as biomarker in differential diagnosis of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). EEG was recorded from 106 patients with AD or FTLD, of which 37 had a definite diagnosis, and 40 controls. Dominant frequency peaks were extracted for all 19 channels, for each subject. The average frequency of the largest dominant frequency peaks (maxpeak) was significantly lower in AD than FTLD patients and controls. Based on ROC analysis, classification could be made with diagnostic accuracy of 78.9%.
Exploring the validity of scores from the Rosenberg Self-Esteem Scale (RSES) in Burundi: A multi-strategy approach
Fromont, A. et al. (2017) Exploring the validity of scores from the Rosenberg Self-Esteem Scale (RSES) in Burundi: A multi-strategy approach. Journal of Psychology in Africa, Vol. 27, no.4, pp. 316-324.
The present study aimed to validate the Rosenberg Self-Esteem Scale (RSES) in Burundi, through a multi-strategy approach used in cross-cultural studies. Respondents were 906 health workers (men =56%; caregivers 60%). They responded to a bilingual version of RSES. We utilized Confirmatory Factorial Analysis (CFA) with structural equation modelling and a back translation test to explore the structure of the RSES and the reliability of scores from the scale.